External validity of trials should be taken into account before asthma drug candidates reach market authorisation

External validity of trials should be taken into account before asthma drug candidates reach market authorisation.

Should social network structure be taken into account in elections?

If the social network structure among the voters in an election is known, how should this be taken into account by the voting rule? In this brief article, I argue, via the maximum likelihood approach to voting, that it is optimal to ignore the social network structure altogether—one person, one vote.

Torsades de pointes: Should ECG be taken from all patients before surgery? A case report

Torsades de pointes is a rare but potentially lethal arrhythmia which mainly occurs in the setting of a prolonged QT interval. ECG is a reliable tool to detect such abnormalities, routinely taken from all patients over 40 who undergo surgery. We describe the case of a 35-year-old woman with torsades de points arrhythmia after hysterectomy surgery. Most likely, our patients had long QT syndro...

What characteristics of the gamers' profile should be taken into account in player-centred game design?

In this paper, we introduce the theory of trait Emotional Intelligence (‘trait EI’) as a personality theory that could assist in exemplifying the gamers’ profile and contribute to the design of player-center game experiences. Data from two studies (a game-specific and a game-general one) led to a number of playercentered playability principles that could inform the design of adaptable games and...

Secondhand smoke exposure effect on elastin degradation markers: which factors should be taken into account?

Affi liations: From the Section of Pulmonary and Critical Care Medicine, Asthma Clinical Research Center (Dr Hanania), Baylor College of Medicine; Division of Pulmonary and Critical Care Medicine (Dr Celli), Brigham and Women’s Hospital, Harvard University; Division of Pulmonary Disease and Critical Care Medicine (Dr Donohue), University of North Carolina at Chapel Hill; and Clinical Research, ...